The Sequential Combination Paradigm in Epigenetic Therapy

Combination therapy with BOTOX and fillers: the new rejuvnation paradigm.

Until relatively recently, restoration of appearance by replacement of lost facial volume and muscular relaxation has been an illusory goal. With advances in the commercial availability of newer filling agents and a better understanding of the clinical esthetic effects of botulinum toxin A, remarkably sophisticated and refined results can now be achieved by using these noninvasive techniques. T...

Combination and sequential therapy with PTH and bisphosphonates.

with anti-resorptive agents, such as bisphosphonates, offer the potential for synergistic benefits for patients at high risk of fracture. Although fracture endpoint studies exist for monotherapy with either bisphosphonates or PTH, such studies do not exist for treatment strategies involving combined or sequential use of PTH and bisphosphonates, and only studies with surrogate endpoints currentl...

Is the Sequential Travel Forecasting Paradigm Counterproductive?

The sequential travel forecasting procedure is widely accepted without question by transportation planners, yet its origins are obscure, its effects on practice and research may well be negative, and by focusing attention on individual steps, it tends to impede overall progress in improving forecasting methods. Alternatives to the sequential procedure proposed by researchers over the past 30 ye...

Kaiso and Prognosis of Cancer in the Current Epigenetic Paradigm

The role of teriparatide in sequential and combination therapy of osteoporosis.

Osteoporosis is complicated by the occurrence of fragility fractures. Over past years, various treatment options have become available, mostly potent antiresorptive agents such as bisphosphonates and denosumab. However, antiresorptive therapy cannot fully and rapidly restore bone mass and structure that has been lost because of increased remodelling. Alternatively recombinant human parathyroid ...